Network / Labs
We strive to build a network of matrix biology enthusiastic researchers in Switzerland.
Research interests: Developing active ingredients for skin care or cosmetic products. Skin aging, skin barrier, extracellular matrix biology.
Expertise: skin biology, ECM, collagen
Lab website: http://www.biozentrum.unibas.ch/research/groups-platforms/group/unit/lim/
Research interests: tissue mechanics, physical aspects of cancer progression, cell-cell and cell-ECM interactions, particularly structural and functional aspects of basement membranes, translational research in cancer mechanics.
Expertise: quantitative biopsy-wide nanomechanical profiling, clinical application of AFM.
Research interests: Integrins, cell-matrix adhesion and remodeling.
Expertise: live-cell imaging, integrins, talin, cell adhesion, cell migration, c-kit, stem cells, and metabolism.
Keynote Speaker of the SSMB 2019 Annual Meeting
Feige, Jerome N
Group Leader and Adjunct lecturer
Skeletal muscle & Aging Lab, Nestlé Institute of Heath Sciences
Lab website: https://www.nestleinstitutehealthsciences.com/scienceandtechnology/brainhealth#topic02
Research interests: We study the molecular, cellular and nutritional mechanisms leading to the dysfunction of skeletal muscle during ageing, particularly the condition of sarcopenia, in which muscle mass and muscle function decline due to age. Sarcopenia involves multiple pathophysiological processes such as impaired neuro-muscular transition, altered excitation/contraction coupling, impaired regenerative capacity linked to stem cell exhaustion, defects of mitochondrial and energy metabolism in myofibers, and finally marbling of skeletal muscle with fat and fibrosis.
Our recent work has demonstrated that neuromuscular dysfunction is a major driver of sarcopenia (Pannerec et al, Aging 2016) and that remodeling of the extracellular matrix (ECM) during muscle regeneration is blunted in the aged muscle stem cell niche and can be targeted therapeutically (Lukjanenko et al., Nature Medicine 2016).
Expertise: Muscle biology, aging, exercise, molecular control of rodent physiology.
Research interests: By interfacing advanced biomaterials engineering, microtechnology and stem cell biology, the overarching goal of the Lutolf Laboratory is to uncover mechanisms of stem cell fate regulation; knowledge that will contribute to better ways to grow stem cells in culture and use them for various applications. A major current focus of the lab is on coaxing stem cells in vitro into miniature, organ-mimicking constructs, termed ‘organoids’, by exposing them to well-controlled artificial signaling microenvironments.
Expertise: Bioengineering, Stem Cells, Biomaterials, Tissue Engineering, Microfluidics, Single Cell Analysis, High-Throughput Screening.
Keynote Speaker of the joint Swiss and German Matrix Biology 2018 Meeting
Research interests: Experimental continuum mechanics, applied for the solution of challenging problems in engineering and medicine. The deformation mechanisms of soft biological tissues in human organs is characterized at all relevant length scales and is described with appropriate mathematical models. Knowledge of tissues properties is used for diagnosis, and for biomedical simulations. Tissue engineered and synthetic biomedical materials, mesh implants, and cardiovascular prosthetic devices are evaluated in terms of “mechanical biocompatibility”. See also: www.hochschulmedizin.uzh.ch/zurichheart, www.hochschulmedizin.ch/skintegrity.
Expertise: Multiaxial in-situ and in-vivo biomechanical testing, traction force microscopy, cell-matrix interaction, chemo-mechanical coupling, fracture mechanics of soft collagenous tissues, multiphase continuum models, discrete fiber network models.
Research Unit of Prof. Viola Vogel, Laboratory of Applied Mechanobiology, Department of Health Sciences and Technology, ETH Zürich
Lab website: http://www.appliedmechanobio.ethz.ch/
Research interests: Secreted kinases and extracellular phosphorylation.
Expertise: bioinformatics, computational biology, personalized health
Tissue Engineering and Biofabrication, Department of Health Sciences and Technology, ETH Zürich
Lab website: www.biofabrication.ethz.ch
Research interests: Cartilage tissue engineering and regeneration.
Expertise: Cartilage matrix, scaffolds, tissue engineering, inflammation, biomaterials, bioprinting, growth factors.