• Network / Labs

    We strive to build a network of matrix biology enthusiastic researchers in Switzerland.

    Aarau

    Wandrey, Franziska
    Research and Study Manager
    Mibelle Group Biochemistry
    Website: http://mibellebiochemistry.com/
    Research interests: Research collaborations in skin aging for new molecular biology concepts to develop active ingredients for cosmetics. Always looking for new partners involved in cutting edge skin and anti-aging research.
    Expertise: In vitro and clinical testing of cosmetic active ingredients. Skin models, skin biology.
     

    Basel

    Imfeld, Dominik
    R&D Skin Care
    DSM Nutritional Products Ltd,

    Website: https://www.dsm.com/corporate/markets-products/markets/personal-care.html
    Research interests: Developing active ingredients for skin care or cosmetic products. Skin aging, skin barrier, extracellular matrix biology.
    Expertise: skin biology, ECM, collagen

     

     

    Plodinec, Marija
    Oberassistent in the group of Prof. Dr. Roderick Lim.
    Biozentrum and the Swiss Nanoscience Institute, Dept. Structural Biology and Biophsycis, University of Basel

    Lab website: http://www.biozentrum.unibas.ch/research/groups-platforms/group/unit/lim/
    Research interests: tissue mechanics, physical aspects of cancer progression, cell-cell and cell-ECM interactions, particularly structural and functional aspects of basement membranes, translational research in cancer mechanics.
    Expertise: quantitative biopsy-wide nanomechanical profiling, clinical application of AFM.

    Bern

    Chiquet, Matthias
    Professor
    Dept. Orthodontics and Dentofacial Orthopedics, University of Bern
    Lab website: http://www.ortho.zmk.unibe.ch/ueber_uns/team/personen/prof_dr_chiquet_matthias/
    Research interests: Role of extracellular matrix in cleft palate etiology and repair.
    Expertise: Palate repair, transforming growth factor-beta, bone morphogenetic protein, matrix metalloproteinases, cleft lip/palate, palate morphogenesis, extracellular matrix, wound healing

     
    Degen, Martin
    Oberassistent
    Zahnmedizinische Kliniken, University of Bern
    Lab website: http://www.ortho.zmk.unibe.ch/ueber_uns/team/personen/degen_martin/
    Research interests: Epidermal transcription factors linking cleft palate to altered wound healing.
    Expertise: Wound healing, Tenascins, cancer research.
     
     
    Gazdhar, Amiq
    Oberassistent
    Department of Pulmonary Medicine, University of Bern
    Lab website: http://www.dkf.unibe.ch/services/staff/dr_gazdhar_amiq/index_eng.html​
    Research interests: Lung repair and regeneration.
    Expertise: Stem cells and gene therapy.
     
     
    Schittny, Johannes C.
    Professor
    Institute of Anatomy, University of Bern
    Lab website: http://www.anaweb.ch/ueber_uns/abteilungen/index_ger.php?key=schi#select
    http://www.anaweb.ch/ueber_uns/abteilungen/detail/index_ger.php?key=schi&id=37
    Research interests: Lung development, lung Imaging, pulmonary particle deposition, basement membranes, tenascins, laminins, integrins.
    Expertise: Lung development, extracellular matrix, basement membrane, high resolution 3D lung imaging (X-ray tomographic microscopy and microCT), lung ventilation and ventilation physiology, stereology (quantitative estimations in a 3D-volume on 2D-sections), breading the tenascin-C knockout mouse (Forsberg, E., et al., Proc Natl Acad Sci U S A, 1996. 93(13):6594-9).
     

    Fribourg

    Dengjel, Joern
    Professor
    Dep. of Biology, University of Fribourg
    Lab website: http://www.unifr.ch/biology/research/dengjel/
    Research interests: Role of collagen VII in cell homeostasis.
    collagen VII, proteomics, mass spectrometry, autophagy
    Expertise: proteomics

     
    Jazwinska, Anna
    Professor
    Dep. of Biology, University of Fribourg
    Lab website: http://www.unifr.ch/biology/research/jazwinska/
    Research interests: Organ regeneration in zebrafish. How and why organs can or cannot regenerate after injury are important questions. Humans are not able to regenerate their damaged heart and limbs, but certain vertebrates possess such capabilities. The zebrafish is the ideal model for investigation of regeneration, due to its power to restore complex organs and the existence of molecular genetic tools. Conceptual understanding of the natural mechanisms of regeneration will pave the way for novel medical strategies for treatment of injuries in people. In our laboratory, we are exploring the molecular and cellular triggers of heart and fin regeneration in zebrafish, and have made some intriguing discoveries.
    Expertise: regeneration, cell differentiation and plasticity, organ homeostasis, wound healing upon injury.

    Geneva

    Wehrle-Haller, Bernhard

    Professor
    Wehrle-Haller Lab, Cell Physiology and Metabolism, University of Geneva, Switzerland
    Lab website: http://www.unige.ch/medecine/phym/fr/groupes/645wehrle-haller/

    Research interests: Integrins, cell-matrix adhesion and remodeling.
    Expertise: live-cell imaging, integrins, talin, cell adhesion, cell migration, c-kit, stem cells, and metabolism.

    Lausanne

    Feige, Jerome N
    Group Leader and Adjunct lecturer
    Skeletal muscle & Aging Lab, Nestlé Institute of Heath Sciences
    Lab website: https://www.nestleinstitutehealthsciences.com/scienceandtechnology/brainhealth#topic02
    Research interests: We study the molecular, cellular and nutritional mechanisms leading to the dysfunction of skeletal muscle during ageing, particularly the condition of sarcopenia, in which muscle mass and muscle function decline due to age. Sarcopenia involves multiple pathophysiological processes such as impaired neuro-muscular transition, altered excitation/contraction coupling, impaired regenerative capacity linked to stem cell exhaustion, defects of mitochondrial and energy metabolism in myofibers, and finally marbling of skeletal muscle with fat and fibrosis.
    Our recent work has demonstrated that neuromuscular dysfunction is a major driver of sarcopenia (Pannerec et al, Aging 2016) and that remodeling of the extracellular matrix (ECM) during muscle regeneration is blunted in the aged muscle stem cell niche and can be targeted therapeutically (Lukjanenko et al., Nature Medicine 2016).
    Expertise: Muscle biology, aging, exercise, molecular control of rodent physiology.

     

     

    Lütolf, Matthias

    Professor
    Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV) and School of Engineering (STI), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne.
    Lab website: https://lscb.epfl.ch

    Research interests: By interfacing advanced biomaterials engineering, microtechnology and stem cell biology, the overarching goal of the Lutolf Laboratory is to uncover mechanisms of stem cell fate regulation; knowledge that will contribute to better ways to grow stem cells in culture and use them for various applications. A major current focus of the lab is on coaxing stem cells in vitro into miniature, organ-mimicking constructs, termed ‘organoids’, by exposing them to well-controlled artificial signaling microenvironments.
    Expertise: Bioengineering, Stem Cells, Biomaterials, Tissue Engineering, Microfluidics, Single Cell Analysis, High-Throughput Screening.

    Zürich

    Bordoli, Mattia
    Oberassistent
    Research Unit of Prof. Sabine Werner, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology ETH
    Institute of Molecular Health Sciences, Swiss Federal Institute of Technology ETH Zurich
    Lab website: http://www.mhs.biol.ethz.ch/research/werner/group-members-werner/bordoli.html
    Research interests: Regulation of extracellular matrix remodeling in health and disease.
    Expertise: Secreted kinases, extracellular phosphorylation, fibrosis, tumor invasion, regeneration, wound healing


    Ewald, Collin
    Assistant Professor
    Extracellular Matrix Regeneration Laboratory, Department of Health Sciences and Technology, ETH Zürich
    Lab website: http://ewaldlab.com
    CV on LinkedIn, Twitter: @CollinEwald
    Research interests: Our recent work has shown that many health- and longevity-promoting interventions re-activate the expression of extracellular matrix (ECM) genes during aging (Ewald et al., Nature 2015, PMID:25517099). This ECM enhancement is required and sufficient for extending the lifespan of C. elegans. Our research efforts are focusing on exploring the mechanism(s) of how prolonged ECM homeostasis promotes healthy aging.
    Expertise: C. elegans ECM, aging, protein aggregation, neurodegeneration (Alzheimer's disease), Insulin/IGF-1 signaling, NADPH oxidases, ROS, oxidative stress.


    Giunta, Cecilia
    Oberassistent
    Division of Metabolism, Connective Tissue Unit, University Children's Hospital Zurich
    Lab website: http://www.kispi.uzh.ch/fzk/de/abteilungen/uebersicht/stoffwechsel/Seiten/angeborene-bindegewebskrankheiten.aspx
    CV on http://orcid.org/0000-0002-9313-8257
    Research interests: Improve the understanding of the pathomorphogenesis of the inherited connective tissue disorders Ehlers-Danlos Syndrome and Osteogenesis Imperfecta. Role of collagen folding, secretion, assembly and extracellular matrix homeostasis in health and disease.
    Expertise: Collagen, ER-stress, Ehlers-Danlos Syndrome, Osteogenesis imperfecta, disease variants.


    Moeller, Jens
    Oberassistent
    Research Unit of Prof. Viola Vogel, Laboratory of Applied Mechanobiology, Department of Health Sciences and Technology, ETH Zürich
    Lab website: http://www.appliedmechanobio.ethz.ch/the-laboratory/people/scientific-assistants/Jens0.html
    CV on LinkedIn
    Research interests: We develop advanced 2D/3D culture platforms to study how the biochemical and physical properties of the cellular microenvironment affect cell and microtissue function, with particular focus on the mechanical aspects of immune cells/tissue - bacteria interactions.
    Mechanotransduction, biophysics, surface functionalization, biomaterials.
    Expertise: microfabrication, in vitro 2D/3D cell culture systems, advanced light microscopy, AFM, microfluidics, image analysis.


    Raghunath, Michael
    Professor
    Cell Biology & Tissue Engineering, Institute for Chemistry and Biotechnology (ICBT), Zurich University of Applied Sciences
    Lab websites: www.tissuemodulation.com; www.zhaw.ch
    CV on LinkedIn
    Research interests: Applied matrix biology using macromolecular crowding.
    Collagen, fibrillin, heritable connective tissue disorders, stem cell microenvironment, brown fat differntiation, mesenchymal progenitor cells.
    Expertise:
    adult stem cell differentiation, dermatology, matrix biology


    Snedeker, Jess
    Professor
    University and ETH Zürich
    Lab website: www.biomechanics.ch
    Research interests: Collagen, Tendon, Advanced Glycation Endproducts.
    Expertise: Biomechanics, Biophysics, Collagen, Tendon, Musculoskeletal Science, Biomedical Engineering
    Wolfrum, Christian
    Professor
    Translational Nutrition Biology, Department of Health Sciences and Technology, ETH Zürich
    Research interests: Adipocyte formation and function. Adipocyte Biology, brown adipocyte, white adipocyte, metabolism.
    Expertise: molecular biology, physiology.

     
    Wuetz-Kozak, Karin
    Professor
    Immunoengineering & Regenerative Medicine, Department of Health Sciences and Technology, ETH Zürich
    Research interests: Understanding pathobiological processes; modulating inflammation and inducing regeneration in various tissues; mechanotransduction, TRP channels; inflammation; tissue degeneration and remodeling; interaction between resident cells and bacteria; smart biomaterials.
    Expertise: electrospinning; immunomodulation; cell/molecular biology; inflammatory pathways; mechanical stimulation; TRP channels; biodrug.


    Vogel, Viola
    Professor
    Laboratory of Applied Mechanobiology, Department of Health Sciences and Technology, ETH Zürich
    Lab website: http://www.appliedmechanobio.ethz.ch/
    Research interests: Mechanobiology of the extracellular matrix. Exploiting nanotechnology tools to decipher how bacteria and mammalian cells and micro-tissues exploit mechanical forces to recognize and respond to material properties and to their native environments.
    Expertise: Applied mechanobiology, nanotechnology, molecular dynamics simulations, molecular tension probes, super-resolution microscopy, electron microscopy, traction force microscopy, and substrate patterning and functionalization.

     
    Yalak, Garif

    Oberassistent
    Research Unit of Prof. Viola Vogel, Laboratory of Applied Mechanobiology, Department of Health Sciences and Technology, ETH Zürich
    Lab website: http://www.appliedmechanobio.ethz.ch/
    Research interests: Secreted kinases and extracellular phosphorylation.
    Expertise: bioinformatics, computational biology, personalized health